GeneAbacus
Streamlining Gene Editing Validation
Validate your gene edit in-house with our all-in-one reagent kit, ensuring actionable results in just 5 hours even for high GC content regions and single-base edits.
GeneAbacus: A Standard Workflow For Gene Editing Validation
Streamlining Efficiency and Accuracy
GeneAbacus empowers researchers with a novel worklfow to simplify and accelerate this gene editing validation. The GeneAbacus kit, includes all probes, reagents, consumables and software necessary for gene editing efficiency quantification. All you need to validate your gene edit within a day.
Get in touch to learn more.
A Day Turnaround time
Gain reliable insights into gene editing efficiency and specificity within a single workday. Accelerate your funneling timelines.
Single-Base Precision
Achieve single-nucleotide precision and confidence without the need to optimize probes & protocol parameters
Simple Integration
Compatible with standard laboratory equipment with minimal hands-on time. Minimize disruption to established protocols.
Standard Workflow
Same workflow works for all targets, regardless of GC content. No need to perform dedicated optimizations.
Beyond the Basics: The Science Behind GeneAbacus
Padlock Probes and Rolling Circle Amplification: Precise and Streamlined Target Detection
Our novel approach — padlock probes and rolling circle amplification — offers single-nucleotide precision, removes amplification bias and accuracy for GC-rich regions.
Starting with column-extracted genomic DNA from a gene editing experiment, Our proprietary technology converts edited and wild type sequences into individual fluorescent signals. This enables the precise gene editing validation of cell pools, cell clones and model organisms.
More on how it works here.
GeneAbacus: A Versatile Tool for Gene Edit Validation
Knockout
Gene knockouts are often used for for functional analysis of genes. GeneAbacus provides researchers with reliable knockout confirmation results to move swiftly and confidently from gene edit to function analysis.
Knock-in
Validating knock-ins is crucial for precise gene function studies but often challenging due to the complexity of ensuring accurate gene integration. GeneAbacus simplifies this process, enabling researchers to verify their knock-ins within 5 hours.
Base Editing
Base editing allows for precise single-nucleotide changes, critical for gene correction and research. GeneAbacus streamlines the validation process and ensures accurate confirmation of single base edits.
Prime Editing
Prime editing offers precise, versatile gene modifications ranging from small to large edits. GeneAbacus efficiently confirms prime edits to accelerate research journeys and discoveries.
GeneAbacus Empowers Your Discoveries
Faster Analysis
Reduce analysis time from weeks to hours. Accelerate your journey towards groundbreaking discoveries.
Confident Decisions
Gain reliable insights into editing efficiency. Make informed decisions about your research path.
Simplified Workflow
Streamline your workflow with a user-friendly and precise assay. Free up valuable research time.
Product Specifications
| Supported species | Data output | Genomic DNA input | Probe set up | Sample compatibility | Microscope Objective | Protocol time |
| Human, mouse |
|
|
Custom probes + internal control | Pool analysis or clonal selection | 20x, NA >0.5, WD ~500 nm | ~5 hours |
Ready to Experience the GeneAbacus Difference?
Let’s Build Your Future Together
Download Resources
Customer Case Study, July 2024
Collab with SciLifeLab, April 2023
Info Brochure
Scientific Poster