High-Fidelity Genome Editing Validation. Comprehensive On- and Off-Target Confirmation.

LockSeq is a targeted NGS library prep platform providing the sequence-level truth required for robust genome editing characterization. Achieve unmatched target recovery and high sensitivity on panels comprising of hundreds of sites.

PLATFORM ADVANTAGES

Enabling High-Fidelity and Massive Scalability

Minimizing Target Dropout

Ensure your characterization is complete. Our ligation-locked chemistry is engineered to minimize stochastic target dropout, providing consistent coverage across every targeted locus and eliminating the "genomic blind spots" common in standard multiplex PCR.

Sequence-Level Resolution

Detect rare variants with absolute confidence. Achieve a validated Limit of Detection of <0.1% VAF with a noise floor suppressed by consensus sequencing, ensuring your data is built on biological truth, not stochastic assay noise.

Predictable Scaling without Complexity

Scale your discovery panels without sacrificing accuracy. Maintain uniform performance from single-plex assays to massive 1,000-plex panels. By reducing potential molecular interaction points by 75%, we eliminate sequencing background and optimization cycles.

High Panel Flexibility

Mix your target panels with zero friction. LockSeq's molecular lock capture mechanism allows you to "mix and match" coordinates or add new targets to existing panels without risk of interference.

Seamless Platform Integration

LockSeq produces inherently neutral circular templates that deliver high concordance (R > 0.99) across both Illumina and Oxford Nanopore platforms.

Karolinska Institute
EARLY ACCESS

Join Our Pilot Phase

We are currently onboarding a limited number of academic and industrial partners for technical validation pilots. We function as your specialized back-end service: you send DNA; we deliver UMI-corrected NGS reports.

To demonstrate LockSeq's performance on your most challenging panels while providing you with high-resolution validation data without the need for capital equipment or in-house optimization.

EARLY ACCESS PROGRAM